Dual Control of Replication Timing

Dual control of replication timing. Stochastic onset but programmed completion of mammalian chromosome duplication.

In mammalian cells, DNA replication proceeds according to a precise temporal order during the S phase, but how this program is controlled remains poorly understood. We analyzed the replication-dependent bromodeoxyuridine banding of chromosomes in Chinese hamster cells treated with the spindle poison nocodazole. In these cells, nocodazole induces a transient mitotic arrest, followed by DNA re-re...

Control of Replication Timing by a Transcriptional Silencer

BACKGROUND Eukaryotic DNA replication starts at many origins. Some origins are used early in S phase, while others are programmed to fire later. In general, late replication is correlated with transcriptional inactivity and with location near the nuclear periphery. However, the mechanisms that determine replication timing are unclear, and the cause-and-effect relationship between late replicati...

Telomere-binding proteins play roles in control of replication timing

Comment on: Tazumi A, et al. Genes Dev 2012; 26:2050-62.

SnapShot: Replication Timing

Optimal Integral State Feedback Control of HCCI Combustion Timing

Homogenous Charge Compression Ignition (HCCI) engines hold promise of high fuel efficiency and low emission levels for future green vehicles. But in contrast to gasoline and diesel engines, HCCI engines suffer from lack of having direct means to initiate combustion. A combustion timing controller with robust tracking performance is the key requirement to leverage HCCI application in production ...